BKAT Critical Care Practice Exam

Question: 1 / 400

What occurs at high doses of dopamine (over 10 mcg/kg/min)?

Activates dopaminergic receptors

Activates alpha receptors, causing vasoconstriction

At high doses of dopamine, specifically when the dosage exceeds 10 mcg/kg/min, the predominant effect is the activation of alpha receptors, leading to vasoconstriction. While dopamine at lower doses primarily stimulates dopaminergic receptors to enhance blood flow to renal and mesenteric regions, high doses shift the emphasis to alpha receptor activity. This activation results in systemic vasoconstriction, which can increase vascular resistance and, consequently, blood pressure.

This understanding is crucial in critical care settings where managing blood pressure and perfusion is essential for patient outcomes. The pharmacodynamic profile of dopamine illustrates its dose-dependent effects, where low doses may provide benefits like renal perfusion, but higher doses can exacerbate cardiovascular workload and potentially lead to complications associated with vasoconstriction.

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Increases renal blood flow

Decreased heart rate

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